Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide

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Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide

OBJECTIVE Frusemide loaded calcium alginate micropellets, an oral microparticulate delivery system, was statistically optimized exhibiting prolonged therapeutic action minimizing its adverse effects. METHODS Ionotropic Gelation technique was adopted employing 3(2) Factorial designs and keeping the entire process free from organic solvents. Physicochemical and the release characteristics of th...

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Calcium Hydroxide (CH) is commonly employed as intracanal medicament in endodontics. In order to maximize its therapeutic effects, it is essential to develop new approaches for preparing the controlled drug release systems which, in turn, facilities the dissociation of CH into calcium and hydroxyl ions. This work studies the sustained-controlled release of calcium ions and the effect of pH chan...

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ژورنال

عنوان ژورنال: BioMed Research International

سال: 2013

ISSN: 2314-6133,2314-6141

DOI: 10.1155/2013/819674